Figure 6.

Epistatic effects of D614G mutation on antibody binding

Enrichment values for paired mutant peptides made in either the wild-type Wuhan Hu-1 strain (on the left, D614) or D614G background (on the right, G614) for each patient (numbered at top). All mutant peptides that contained site 614 were included in this analysis (spanning amino acids 599–629). Data are from samples taken day 60 p.s.o. Wilcoxon paired signed-rank test was performed (n = 380 paired mutant peptides). The effect size for all patient samples was small (Wilcoxon r < 0.3), except for patient 10, whose antibodies exhibited a moderate effect (Wilcoxon r = 0.46).