Table 3. Multivariable Regression Analyses.

Table 3 demonstrates various regression analyses across outcomes, including mortality, delayed hypotension, ICU admit and LOS, and intubation. It was demonstrated that 30after3 was associated with significant increased odds of mortality, delayed hypotension, and longer ICU LOS, while controlling for sex, ESRD, HF, disease severity (severe sepsis versus septic shock), obesity, MEDS score, and time to antibiotics.

Variable	Mortality		Delayed Hypotension		ICU Admit		ICU LOS		Intubation
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	β (95% CI)	p	OR (95% CI)	p
30after3a	1.52 (1.03–2.24)	0.035	1.42 (1.02–1.99)	0.040	0.77 (0.6–1.0)	0.088	2.0 (0.5–3.6)	0.010	1.20 (0.78–1.84)	0.416
MEDS scoreb	1.18 (1.13–1.23)	<0.001	1.01 (0.98–1.05)	0.546	1.08 (1.0–1.1)	<0.001	0.2 (0.1–0.4)	0.002	1.03 (0.99–1.08)	0.172
Time to ABxc	1.02 (0.98–1.07)	0.362	1.02 (0.97–1.08)	0.392	1.01 (1.0–1.1)	0.695	0.02 (−0.2–0.3)	0.886	1.00 (0.95–1.06)	0.919
Obesity	0.74 (0.48–1.13)	0.158	1.03 (0.72–1.46)	0.882	1.11 (0.8–1.5)	0.527	−0.2 (−1.8–1.4)	0.816	1.46 (0.95–2.26)	0.088
Male Sex	0.63 (0.44–0.89)	0.009	0.75 (0.56–1.00)	0.053	0.93 (0.7–1.2)	0.580	−0.7 (−2.0–0.6)	0.305	1.06 (0.72–1.56)	0.762
ESRD	1.23 (0.70–2.17)	0.471	1.62 (0.94–2.80)	0.084	1.35 (0.8–2.2)	0.222	1.0 (−1.2–3.2)	0.371	0.83 (0.42–1.64)	0.583
HF	1.34 (0.90–2.00)	0.149	1.48 (1.02–2.16)	0.038	1.71 (1.2–2.4)	0.002	0.4 (−1.2–1.9)	0.653	0.88 (0.55–1.40)	0.590
Shock	1.05 (0.69–1.60)	0.822	7.80 (5.59–10.90)	<0.001	2.98 (2.2–4.0)	<0.001	−1.0 (−2.7–0.7)	0.234	1.98 (1.23–3.21)	0.005

Legend: All estimated by Multivariable Logistic Regression analyses, except for ICU LOS, which was analyzed by the methods described in Andersen et al. (25). β represents a regression coefficient from a linear model, 2.0 represents an ICU LOS of ~2 days longer in the 30after3 group, after adjustment for the other covariates in the model.

^A)vs. 30by3

^B)per 1-point increase in the MEDS score

^C)per 1hour increase in time to ABx.