Table 3.
Minimum inhibitory concentrations of KFF-acpP, RXR-acpP and Tat-acpP conjugates tested against wt Salmonella enterica serovar Typhimurium strain SL1344 versus its isogenic mutant ΔphoP, and wild-type Salmonella enterica serovar Typhimurium strain LT2 versus its isogenic mutant PhoPC (∼105 cfu/ml). Cyan background denotes the conjugate for which MIC values against Salmonella mutants differed from those of the respective wt. Growth curves are shown in Supplementary Figures S4 and S5
| MIC in μM | ||||
|---|---|---|---|---|
| Name | SL1344 wt |
SL1344 ΔphoP |
LT2 wt |
LT2 PhoPC |
| KFF-acpP | 1.25 | 1.25 | 1.25 | 1.25 |
| KFF-acpP-scr | >10 | ≥10 | >10 | >10 |
| KFF | >10 | 10 | >10 | >10 |
| RXR-acpP | 2.5 | 1.25–2.5 | 1.25 | 2.5 |
| RXR-acpP-scr | ≥10 | 5 | 10 | >10 |
| RXR | >10 | >10 | >10 | >10 |
| Tat-acpP | 5 | 2.5 | 2.5–5 | 10 |
| Tat-acpP-scr | >20 | 20 | >20 | >20 |
| Tat | >20 | >20 | >20 | >20 |
| acpP | >20 | >20 | >20 | >20 |