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. 2021 Apr 13;49(8):4294–4307. doi: 10.1093/nar/gkab250

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — SHAPELoop accurately identifies the structural switch in the P5c subdomain. The structural switch between the tetraloop and the heptaloop is shown. The P5c subdomain folds into the tetraloop form in the absence of Mg²⁺ (A) and the heptaloop form in the presence of Mg²⁺ (B). (C) The U30C mutant, which is designed to stabilize the tetraloop. (D) The G39A mutant, which is designed to stabilize the heptaloop. The SHAPE reactivities are shown on the structures using a coloring scheme, and penalties are shown as heat maps. Mutated residues are marked with black circles. The residues are renumbered compared to the original paper (76).