Table 5.
Correlation Between Methylation Detection Rate and the Clinicopathologic Features in CRC Stool Samples
| Clinicopathological Parameters | mSDC2 Rate (%) | p value | mTFPI2 Rate (%) | p value | Total Positive Detection Rate (%) | p value |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male (n=38) | 73.7 (28/38) | 0.422 | 89.5 (34/38) | 1 | 94.7 (36/38) | 1 |
| Female (n=23) | 82.6 (19/23) | 91.3 (21/23) | 91.3 (21/23) | |||
| Age | ||||||
| ≥ 60 (n=27) | 70.4 (19/27) | 0.269 | 62.2 (23/27) | 0.465 | 88.9 (24/27) | 0.447 |
| < 60 (n=34) | 82.4 (28/34) | 94.1 (32/34) | 97.1 (33/34) | |||
| Location | ||||||
| Left (n=52) | 80.8 (42/52) | 0.218 | 92.3 (48/52) | 0.456 | 94.2 (49/52) | 1 |
| Right (n=9) | 55.6 (5/9) | 77.8 ((7/9) | 88.9 (8/9) | |||
| Size | ||||||
| ≥ 3 cm (n=32) | 84.4 (27/32) | 0.153 | 96.9 (31/32) | 0.156 | 96.9 (31/32) | 0.535 |
| < 3 cm (n=29) | 69.0 (20/29) | 82.8 (24/29) | 89.7 (26/29) | |||
| Clinical stage | ||||||
| I–II (n=26) | 76.9 (20/26) | 0.984 | 88.5 (23/26) | 1 | 92.3 (24/26) | 1 |
| III–IV (n=35) | 77.1 (27/35) | 91.4 (32/35) | 94.3 (33/35) | |||
| Symptom status | ||||||
| Symptomatic (n=36) | 83.3 (30/36) | 0.085 | 88.9 (32/36) | 0.177 | 97.2 (35/36) | 0.074 |
| Asymptomatic (n=25) | 64.0 (16/25) | 72.0 (18/25) | 80.0 (20/25) |
Notes: mSDC2 rate refers to detection rate of methylated SDC2; mTFPI2 rate refers to detection rate of methylated TFPI2; total positive rate refers to integrated detection rate of methylated SDC2 and TFPI2.