Table 8.
Comparison of Integrated Detection of Methylated SDC2 and TFPI2 to Other Screening Methods in CRC
| Method | Methylation Detection (+) | Methylation Detection (-) | p value | Sensitivity (%) |
|---|---|---|---|---|
| FOBT | ||||
| FOBT+ | 44 | 1 | <0.001 | 73.7 (45/61) |
| FOBT- | 13 | 3 | ||
| AFP | ||||
| AFP+ (>8.78 ng/mL) | 4 | 1 | <0.001 | 8.2 (5/61) |
| AFP- (≤8.78 ng/mL) | 53 | 3 | ||
| CEA | ||||
| CEA+ (>5 ng/mL) | 3 | 1 | <0.001 | 65.6 (4/61) |
| CEA- (≤5 ng/mL) | 54 | 3 | ||
| CA125 | ||||
| CA125+ (>35 U/mL) | 9 | 0 | <0.001 | 14.8 (9/61) |
| CA125- (≤35 U/mL) | 48 | 4 | ||
| CA153 | ||||
| CA153+ (>28 U/mL) | 1 | 0 | <0.001 | 1.6 (1/61) |
| CA153- (≤28 U/mL) | 56 | 4 | ||
| CA199 | ||||
| CA199+ (>37 U/mL) | 7 | 1 | <0.001 | 13.1 (8/61) |
| CA199- (≤37 U/mL) | 50 | 3 |
Notes: Methylation detection (+) refers to positive detection of integrated methylated SDC2 and TFPI2; methylation detection (-) refers to negative detection of integrated methylated SDC2 and TFPI2. Chi-square test was used in that comparison.