ACTRN12620001091998 2020.

Study name	A randomised controlled trial of the efficacy and safety of an inhaled corticosteroid and long acting beta agonist reliever therapy regimen in children with mild asthma‐ CARE: Children's Anti‐inflammatory REliever
Methods	Randomised controlled trial
Participants	Children aged 5‐15 with a doctor diagnosis of asthma (parent/participant‐reported) using an SABA reliever as sole asthma medication in the previous three months
Interventions	Budesonide‐formoterol PMI 50 mcg/3 mcg, two puffs via spacer as required. Comparator‐ salbutamol PMI 100mcg as required via spacer
Outcomes	Asthma attacks, severe asthma attacks as rate per participant per year,least one asthma attack (moderate and severe) and severe attack, time to first asthma attack (moderate and severe) and severe attack. Days in Hospital, FeNo, FEV1, ACQ‐5, lost school days, lost work days (parents/guardians), total systemic corticosteroid dose, growth
Starting date
Contact information	Dr Lee Hatter Address Medical Research Institute of New Zealand Level 7 CSB Building Wellington Hospital Riddiford Street Newtown Wellington 6021 lee.hatter@mrinz.ac.nz (public and scientific enquiries)
Notes