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. 2021 Mar 9;10:e62585. doi: 10.7554/eLife.62585

Figure 3. Examples of differential protein expression with age.

(A) Decreased expression of HIST1H1B, a histone protein (B) increased expression of ACTA2, a marker of renal fibrosis, (C) decreased expression of NCLN, a part of the endoplasmic reticulum, and (D) decreased expression of CISD2, which is involved in mitochondrial autophagy.

Figure 3.

Figure 3—figure supplement 1. Functional enrichment of differentially expressed proteins and networks.

Figure 3—figure supplement 1.

We evaluated the proteins for functional enrichment of GO categories using ClusterProfiler and observed overrepresentation of genes associated with 186 terms (adjusted p-value < 0.01) representing a wide array of (A) biological processes, (B) cellular compartments, and (C) molecular functions.