Figure 2.

Chemosuppressive antimalarial activity of GIE against PbANKA infected mice. Groups of ICR mice were infected with 1 × 10⁷ PbANKA infected erythrocytes and administered orally with 10, 50, and 100 mg/kg of GIE for 4 consecutive days. (a) Parasitemia, (b) PCV, and (c) BW were measured. (d) MST was also determined. Results were presented as mean ± SEM. UN: untreated mice, GI10: 10 mg/kg of GIE treated mice, GI50: 50 mg/kg of GIE treated mice, GI100: 100 mg/kg of GIE treated mice, and CQ: 10 mg/kg of chloroquine treated mice.  ^∗P < 0.05,  ^∗∗P < 0.01, and  ^∗∗∗P < 0.001 compared to either UN or D0 after infection.