Table 2.
The key therapeutic targets of DNt in the treatment of NAFLD.
| No. | Target name | Gene symbol | Uniprot ID | Degree value | Closeness centrality value |
|---|---|---|---|---|---|
| 1 | Interleukin-6 | IL6 | P05231 | 24 | 0.55 |
| 2 | Mitogen-activated protein kinase 8 | MAPK8 | P45983 | 21 | 0.53 |
| 3 | Vascular endothelial growth factor A | VEGFA | P15692 | 20 | 0.52 |
| 4 | Caspase-3 | CASP3 | P42574 | 17 | 0.50 |
| 5 | Myc proto-oncogene protein | MYC | P01106 | 16 | 0.49 |
| 6 | Amyloid-beta A4 protein | APP | P05067 | 16 | 0.50 |
| 7 | Serum albumin | ALB | P02768 | 16 | 0.48 |
| 8 | Peroxisome proliferator-activated receptor gamma | PPARG | P37231 | 14 | 0.47 |
| 9 | Transcription factor p65 | RELA | Q04206 | 14 | 0.47 |