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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Biochem Pharmacol. 2020 Nov 6;187:114321. doi: 10.1016/j.bcp.2020.114321

Figure 2: Chemical structures of adenosine and potent nucleoside and non-nucleoside adenosine kinase inhibitors.

Figure 2:

Early ADK inhibitors include NH2-dADO, 5-IT and 5’d-5IT [48]. Detailed structure-activity studies based on these molecules and optimization of novel chemotypes identified from high-throughput screening campaigns have led to the generation of the diverse array of ADK inhibitors shown here [45–55].