Table 1: Gated proteolytic machines and ClpP activators are found in diverse bacterial species.
Tabular lists of genomic features were downloaded from the NCBI Genome base and annotations verified by BLAST, UniProt entries, and citations in PubMed. These annotations are based on the following strains: E. coli str. K-12 substr. MG1655, N. meningitidis MC58, Caulobacter vibrioides (crescentus) CB15 Staphylococcus aureus subsp. aureus NCTC8325, Bacillus subtilis subsp. Subtilis str.168, Pseudomonas aeruginosa PAO1, C. trachomatis 434/Bu, L. monocytogenes EGD-e, Clostridioides difficile 630, M. smegmatis mc2155, M. tuberculosis H37Rv, and M. leprae TN. Gated proteases are in shaded columns, activators are unshaded.
| Bacterial Species | FtsH | Lon | HsIVU | CIpP | CIpA | CIpX | CIpC | CIpE | Proteasome | Mpa | PafE |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Escherichia coli | + | + | + | + | + | + | − | − | − | ||
| Neisseria meningitidis | + | + | − | + | + | + | − | − | − | ||
| Caulobacter crescentus | + | + | + | + | + | + | − | − | − | ||
| Staphylococcus aureus | + | − | + | + | − | + | + | − | − | ||
| Bacillus subtilis | + | 2 | + | + | − | + | + | + | − | ||
| Pseudomonas aeruginosa | + | + | + | 2 | + | + | − | − | − | ||
| Chlamydia trachomatis | + | + | − | 2 | − | + | − | − | − | ||
| Listeria monocytogenes | + | − | + | 2 | − | + | + | + | − | ||
| Clostridium difficile | + | + | − | 2 | − | + | + | − | − | ||
| Mycobacterium smegmatis | + | + | − | 2 | − | + | + | − | + | + | + |
| Mycobacterium tuberculosis | + | − | − | 2 | − | + | + | − | + | + | + |
| Mycobacterium leprae | + | − | − | 2 | − | + | + | − | + | + | + |