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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Free Radic Biol Med. 2021 Mar 17;167:218–231. doi: 10.1016/j.freeradbiomed.2021.03.013

Figure 2. Schematic diagram of epigenetic regulations of Nrf2 signaling by noncoding RNAs in the pathogenesis of heart failure.

Figure 2.

Keap1-dependent Nrf2 degradation in the normal condition (A); miRNAs inhibit Nrf2 signaling by directly inhibiting Nrf2 translation (B); miRNAs enhance Nrf2 signaling by indirectly inhibiting Keap1 translation (C); miRNA impacts Nrf2 signaling by inhibiting the translation of Nrf2 transcriptional enhancers (Sirt1/Sirt6) (D); miRNAs enhance Nrf2 signaling by inhibiting the translation of Nrf2 binding competitor (Bach1) (E); lncRNA LINC00261 enhances Nrf2 signaling by sponging miRNA-23a-3p (F); The recruitment of the cardiac transcription factor cysteine-rich protein 2 (CRIP2) and CBP/p300 by lncRNA Sarrah to the Nrf2 promoter for chromatin remodeling and Nrf2 transcriptional activation (G).