Table 1.
Physical characterization, antibacterial activity and cytocompatibility of polymeric antimicrobials synthesized.
| Samples | Mn* | ζ | Numbers of Units † | MIC (μg/mL) | IC50 | HC20 | |||
|---|---|---|---|---|---|---|---|---|---|
| GEA | QDH | DG | P. aeruginosa | E. coli | J774A.1 | RBC | |||
| (g/mol) | mV | PAO1 | ATCC 25922 | (μg/mL) | (μg/mL) | ||||
| pGEA | 5400 | 29.2±1.5 | 25 | – | – | 512 | 512 | 100 | 100 |
| pQDH | 6300 | 23.5±2.3 | – | 20 | – | >2000 | 512 | 5000 | >5000 |
| pGQ | 13500 | 46.7±6.5 | 22 | 25 | – | 512 | 512 | 2000 | 5000 |
| pGQ-DG | 10200 | 38.9±3.3 | 20 | 22 | 4 | 128 | 512 | 2000 | 5000 |
*
based on GPC using PEG as standards.
†
based on 1H NMR; DG was calculated based on AAS of gallium and UV-Vis of DFO:Fe(III) at 430 nm in the final polymer
HC20: concentration causing 20% lysis (hemolysis) of RBC relative to controls