Table 1.

Physiologic Measurements during LPS Infusion

	HD-CPR with iNO (n=10)	HD-CPR (n=10)	p
Heart rate (beats per minute)	120.9 (12.7)	119.0 (9.0)	0.88
Oxygen saturation (%)	95.2 (0.7)	95.3 (0.5)	0.86
Mean aortic pressure (mmHg)	73.2 (4.6)	71.1 (3.3)	0.64
Mean right atrial pressure (mmHg)	11.1 (3.0)	10.6 (2.2)	0.88
Mean pulmonary artery pressure (mmHg)	31.2 (5.5)	28.3 (3.9)	0.60
Coronary perfusion pressure (mmHg)	55.6 (5.5)	54.3 (3.89)	0.81
Aortic diastolic pressure (mmHg)	66.8 (4.9)	64.9 (3.4)	0.70
Aortic systolic pressure (mmHg)	84.1 (4.9)	81.8 (3.5)	0.64
Cardiac output – 30 min. (L/min.)*	0.80 (0.08)	0.67 (0.09)	0.30
End-tidal carbon dioxide (mmHg)	38.6 (1.1)	38.0 (0.8)	0.57
Brain tissue oxygenation (mmHg)	14.5 (3.4)	13.3 (2.4)	0.71
Relative cerebral blood flow (% baseline)**	108.6 (10.8)	96.7 (7.4)	0.27
Cerebral perfusion pressure (mmHg)***	62.1 (5.3)	60.4 (3.8)	0.75
Duration of LPS infusion (mins.)****	36.5 (4.3)	40.0 (3.3)	0.53

Definition of abbreviations: HD-CPR = hemodynamic-directed cardiopulmonary resuscitation; iNO = inhaled nitric oxide.

Unless otherwise noted, values represent mean from LPS infusion period (45 minutes in animals receiving full duration of LPS infusion), compared using generalized estimating equation regression model. Parenthetic numbers indicate SEM.

^*For intermittent measurements, data distribution for each variable determined with Skewness-Kurtosis test. All data were normally distributed and are displayed as mean and standard error of the mean(in parentheses) and compared using Student’st-test.

^**Calculated as the percent of the pre-LPS infusion baseline value

^***Calculated as difference between MAP and RAP

^****Three animals in HD-CPR with iNO group and two animals in HD-CPR group met criteria for VF induction prior to 45 minutes and thereby received <45 minutes of LPS infusion.