Table 2.

Physiologic Measurements during Cardiopulmonary Resuscitation

	HD-CPR with iNO (n=10)	HD-CPR (n=10)	p
Mean aortic pressure (mmHg)	41.6 (2.00)	36.0 (1.4)	0.005
Mean right atrial pressure (mmHg)	16.6 (1.1)	16.2 (0.8)	0.73
Mean pulmonary artery pressure (mmHg)	29.1 (4.0)	27.3 (2.9)	0.66
Coronary perfusion pressure (mmHg)	20.2 (2.3)	16.2 (1.6)	0.08
Aortic diastolic pressure (mmHg)	32.4 (2.4)	27.1 (1.7)	0.03
Aortic systolic pressure (mmHg)	80.4 (4.8)	84.0 (3.4)	0.45
End-tidal carbon dioxide (mmHg)	24.5 (3.0)	24.0 (2.1)	0.88
Brain tissue oxygenation (mmHg)	28.7 (14.7)	16.7 (10.4)	0.41
Relative cerebral blood flow (% baseline)*	243.2 (54.1)	115.5 (37.3)	0.02
Cerebral perfusion pressure (mmHg)**	25.0 (2.6)	19.1 (1.8)	0.02
Chest compression rate (min-1)	100.8 (0.5)	100.2 (0.3)	0.26
Chest compression depth (cm)	4.2 (0.3)	4.0 (0.2)	0.38
CPR duration (min)	13.2 (1.4)	12.4 (1.3)	0.68
Vasopressor doses (n)	7.8 (1.3)	6.4 (1.2)	0.44
Defibrillation attempts (n)	1 [1, 2]	1 [1, 2]	0.90

Definition of abbreviations: HD-CPR = hemodynamic-directed cardiopulmonary resuscitation; iNO = inhaled nitric oxide.

Mean values from minutes 1–10 of resuscitation period, compared using generalized estimating equation regression model. Parenthetic numbers indicate SEM. Diastolic pressures and coronary perfusion pressure measured during the release phase of chest compressions. Systolic pressures indicate peak pressures during compression phase.

^*Calculated as the percent of the CBF value from the first 60 seconds of CPR

^**Calculated as the difference between MAP and RAP