Table 3.

Post-Resuscitation Physiologic Measurements

	HD-CPR with iNO (n=10)	HD-CPR (n=10)	p
Heart rate (beats per minute)	117.6 (20.4)	134.1 (14.4)	0.42
Oxygen saturation (%)	95.0 (0.7)	94.9 (0.5)	0.94
Mean aortic pressure (mmHg)	61.2 (2.1)	59.6 (1.5)	0.45
Mean right atrial pressure (mmHg)	7.7 (0.8)	9.1 (0.6)	0.11
Mean pulmonary artery pressure (mmHg)	23.8 (5.0)	20.2 (3.5)	0.46
Coronary perfusion pressure (mmHg)	46.8 (2.8)	43.9 (1.9)	0.29
Aortic diastolic pressure (mmHg)	54.6 (2.9)	53.1 (2.0)	0.60
Aortic systolic pressure (mmHg)	72.2 (3.3)	72.1 (2.3)	0.97
End-tidal carbon dioxide (mmHg)	39.3 (0.9)	38.2 (0.7)	0.24
Cardiac output – 5 min. (L/min.)*	0.54 [0.51, 0.89]	0.63 [0.57, 0.92]	0.49
Cardiac output – 30 min. (L/min.)*	1.10 (0.09)	0.89 (0.14)	0.23
Cardiac output – 55 min. (L/min.)*	1.04 (0.13)	1.00 (0.26)	0.90
Brain tissue oxygenation (mmHg)	16.34 (6.0)	18.2 (4.2)	0.75
Cerebral blood flow (% baseline)**	103.9 (14.8)	59.5 (10.1)	0.003
Cerebral perfusion pressure (mmHg)***	53.5 (2.3)	50.5 (1.6)	0.19

Definition of abbreviations: HD-CPR = hemodynamic-directed cardiopulmonary resuscitation; iNO = inhaled nitric oxide.

Unless otherwise noted, values represent means from full hour of resuscitation period, compared using generalized estimating equation regression model. Parenthetic numbers indicate SEM.

^*For intermittent measurements, data distribution for each variable determined with Skewness-Kurtosis test. Normally distributed data displayed as mean and standard error of the mean (in parentheses) and compared using Student’s t-test. Nonparametric data displayed as median and interquartile range (in brackets) and compared using the Wilcoxon rank-sum test.

^**Calculated as the percent of the pre-LPS infusion baseline value

^***Calculated as difference between MAP and RAP