Table 4.

Histopathology and Cytokines

	HD-CPR with iNO (n=8)	HD-CPR (n=8)	p
Cerebral Histopathology
TUNEL (n per low-powered field)	2.5 [0.5, 4]	3.5 [0.5, 6.5]	0.68
IBA-1 (semi-quantitative ranking)	1 [1, 2]	2.5 [1, 3]	0.27
Plasma Cytokines*
IL-1 β	6.7 [2.7, 26.9]	16.0 [7.2, 39.5]	0.23
IL-6	213.3 [142.4, 299.6]	229.0 [162.6, 453.5]	0.63
IL-8	796.0 [723.8, 2429.4]	1577.7 [893.9, 2310.8]	0.84
TNF-α	3.53E4 [3.21E4, 4.21E4]	4.08E4 [3.46E4, 4.51E4]	0.23
Cerebral Cortex Cytokines*
IL-1 β	1.4 [0.6, 1.7]	1.7 [0.8, 2.4]	0.80
IL-6	3.3 [3.1, 3.5]	3.4 [3.2, 3.5]	0.55
IL-8	12.3 [11.6, 17.5]	14.2 [12.2, 27.3]	0.46
TNF-α	9.5 [9.2, 14.7]	13.3 [10.7, 14.7]	0.46
Hippocampus Cytokines*
IL-1 β	1.3 [0.7, 1.8]	1.4 [0.9, 2.0]	0.62
IL-6	3.2 [3.1, 3.6]	3.3 [3.3, 3.6]	0.54
IL-8	15.7 [13.8, 17.0]	15.5 [12.3, 17.3]	0.90
TNF-α	12.5 [9.5, 12.9]	13.1 [11.6, 15.0]	0.32

Definition of abbreviations: HD-CPR = hemodynamic-directed cardiopulmonary resuscitation; iNO = inhaled nitric oxide; TUNEL = terminal deoxynucleotidyl transferase dUTP nick end labeling; IBA1 = ionized calcium binding adaptor molecule 1; IL = interleukin; TNF = tumor necrosis factor.

All data displayed as median and interquartile range (in brackets). Histopathology compared using chi-square test. Cytokines compared using Wilcoxon rank-sum test with Bonferroni correction applied within each tissue (p<0.0125 considered statistically significant).

^*All cytokine concentrations are in pg/mL.