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Comparison of morphology for the adjuvant-only SD-TG formulation, antigen-containing SD-TGI formulation, spray-dried trehalose and the lyophlized vaccine. External morphology of all spray-dried powders shows similar spherical, polydisperse particles that are not fused. Interior structure of the lyophilized vaccine and the spray-dried particles shows similar voids left by the encapsulated emulsion droplets. Scales are provided on the respective images.
