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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Eur J Pharm Biopharm. 2021 Mar 19;163:23–37. doi: 10.1016/j.ejpb.2021.03.007

Table 2.

Chemical and colloidal properties before and after spray drying for adjuvant-only (SD-TG) and antigen containing (SD-TGI) formulations.

ID Nanoemulsion
Droplet Diameter
(nm)		 Polydispersity
Index		 Squalene
Content
(mg/mL)		 GLA
Content
(μg/mL)		 ID93 pH Osmolality
(mOsmol/kg)
Target 120 ± 40 <0.2 13.6 – 20.5 10 ± 2.5 Present 7.5 – 8.5 315 – 415
SD-TG Feedstock Liquid 95.3 ± 0.9 0.05 ± 0.04 19.1 ± 0.4 9.2 ± 0.5 N/A 7.62 383
Reconstituted Powder 96.9 ± 0.2 0.07 ± 0.02 18.8 ± 0.3 9.5 ± 0.4 N/A 7.57 ± 0.04 376 ± 8
SD-TGI Feedstock Liquid 94.9 ± 0.8 0.06 ± 0.01 18.8 ± 0.3 9.3 ± 0.4 Present 7.56 389
Reconstituted Powder 97.6 ± 1.1 0.09 ± 0.01 17.3 ± 0.6 9.0 ± 0.4 Present 7.55 ± 0.01 351 ± 8