Table 3.
Pharmacokinetic parameters of carbamazepine (CBZ), complex prepared by kneading method (KMH), and complex prepared by HLE (CHP-2) when administered orally to Wistar rats
| Parameters | CBZ | KMH | CHP-2 |
|---|---|---|---|
| Cmax (μg/mL) | 20.1 ± 0.46 | 30.3 ± 0.70* | 39.7 ± 0.91*# |
| Tmax (h) | 2 ± 0.00 | 2 ± 0.00 | 1 ± 0.00*# |
| AUC0–24 (h·μg/mL) | 196 ± 6.08 | 298.30 ± 9.25* | 425.25 ± 12.76*# |
| AUC0–∞ (h·μg/mL) | 196.9 ± 6.10 | 299.50 ± 9.28* | 427.95 ± 12.84*# |
| t1/2 (h) | 2.62 ± 0.08 | 2.43 ± 0.08* | 2.68 ± 0.07# |
| Ke (1/h) | 0.264 ± 0.01 | 0.29 ± 0.01* | 0.26 ± 0.01# |
| MRT (h) | 6.5 ± 0.20 | 6.6 ± 0.20 | 6.93 ± 0.21*# |
All values are expressed as mean ± SD; n = 6
AUC area under the curve, t1/2 elimination half-life, Ke elimination rate constant, MRT mean residential time
*p value less than 0.05 (statistically significant) in comparison with CBZ
#p value less than 0.05 (statistically significant) in comparison with KMH