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. 2020 Dec 29;15(5):1358–1375. doi: 10.1002/1878-0261.12887

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Immunophenotypes associated with the different recurrence‐free survival outcomes of prostate cancer patients. (A–C) Consensus‐clustered heatmap by the exemplar genes of NMF selected immune factor and refined by multidimensional scaling random forest to define the immune class; nearest template prediction (NTP) using a signature capturing activated stroma identified two distinct immune response subtypes: immune‐suppressed and immune‐activated classes; in the heat map, high and low single‐sample gene set enrichment scores are represented in red and blue, respectively. Positive prediction of activated stroma signature as per NTP is indicated in brown and its absence is in gray; (D) different recurrence‐free survival of three immunophenotypes in GSE70770 cohort; (E) different recurrence‐free survival of three immunophenotypes in GSE116918 cohort; (F) different recurrence‐free survival of three immunophenotypes in MSKCC cohort. MSKCC, Memorial Sloan‐Kettering Cancer Center. t‐Test, Student t‐test, K‐W test, Kruskal–Wallis test.