Fig. 1. Difference in HAM-D-17 mean change, calculated as baseline scores minus week 4 scores, between patients divided by Study Arm X baseline hsCRP.

Patients with hsCRP levels ≥ 3 mg/L and taking minocycline (CRP⁺/M) showed a significantly larger improvement compared with all other patients. HAM-D-17 = Hamilton Depression Rating Scale. CRP⁺ = baseline hsCRP levels ≥ 3 mg/L. CRP⁻ = baseline hsCRP levels <3 mg/L. M = Minocycline, P = Placebo.