Table 4.
Within and between group analyses on inflammatory biomarkers.
| Minocycline baseline n = 18 Week 4 n = 17 Mean change n = 17 | Placebo baseline n = 21 Week 4 n = 21 Mean change n = 21 | Between-arms statistics | |
|---|---|---|---|
| IL2 mean (SD) (pg/ml) | |||
| Baseline | 0.18 (0.14) | 0.14 (0.12) | |
| Week 4 | 0.22 (0.15) | 0.14 (0.11) | |
| Mean change | −0.035 (0.12) | 0.00 (0.06) | U = 131.5 p = 0.17 |
| IL6 mean (SD) (pg/ml) | |||
| Baseline | 0.87 (0.32) | 0.84 (0.44) | |
| Week 4 | 1.25 (1.7) | 0.76 (0.38) | |
| Mean change | −0.36 (1.59) | 0.07 (0.33) | U = 173.0 p = 0.88 |
| IL8 mean (SD) (pg/ml) | |||
| Baseline | 9.2 (2.64) | 10.77 (3.44) | |
| Week 4 | 11.14 (4.21) | 10.57 (3.62) | |
| Mean change | 1.76 (3.38)* | −0.19 (3.24) | U = 131.0 p = 0.16 |
| IL10 mean (SD) (pg/ml) | |||
| Baseline | 0.30 (0.25) | 0.39 (0.32) | |
| Week 4 | 0.26 (0.21) | 0.43 (0.48) | |
| Mean change | 0.04 (0.33) | −0.04 (0.19) | U = 153.0 p = 0.45 |
| IL13 mean (SD) (pg/ml) | |||
| Baseline | 0.63 (0.49) | 0.63 (0.49) | |
| Week4 | 0.49 (0.46) | 0.58 (0.53) | |
| Mean change | 0.08 (0.31) | −0.12 (0.52) | U = 143.0 p = 0.31 |
| TNFα mean (SD) (pg/ml) | |||
| Baseline | 3.29 (0.75) | 3.18 (0.65) | |
| Week 4 | 3.51 (0.78) | 3.30 (0.73) | |
| Mean change | −0.29 (0.54) | −0.12 (0.31) | U = 135.0 p = 0.21 |
| IFNγ mean (SD) (pg/ml) | |||
| Baseline | 2.97 (2.03) | 2.51 (2.15) | |
| Week 4 | 2.21 (1.61) | 2.76 (1.79) | |
| Mean change | 0.48 (0.93) | −0.24 (1.67) | U = 105.5 p = 0.03 |
IL interleukin, TNF tumour necrosis factor, IFN interferon.
*Within group Wilcoxon Signed Ranks test, p < 0.05.
Bold means that the results are statistically significant.