Table 5.
Sensitivity analysis evaluating the impact of follow-up time on the association of baseline SLICC-FI values with the number of hospitalizations per patient-year of follow-up among SLE patients in the SLICC inception cohort.
| Univariable model | Multivariable model a | |
|---|---|---|
| Incidence Rate Ratio b (95% CI) |
Incidence Rate Ratio b (95% CI) |
|
| Cut point: 2.5 years follow-up | ||
| ≤ 2.5 years follow-up (n=188) | 1.55 (1.27 – 1.91) | 1.35 (1.04 – 1.75) |
| > 2.5 years follow-up (n=1361) | 1.22 (1.15 – 1.30) | 1.21 (1.12 – 1.30) |
| Cut point: 5.0 years follow-up | ||
| ≤ 5.0 years follow-up (n=484) | 1.31 (1.17 – 1.46) | 1.19 (1.06 – 1.35) |
| > 5.0 years follow-up (n=1065) | 1.21 (1.13 – 1.30) | 1.22 (1.13 – 1.31) |
| Cut point: 7.5 years follow-up | ||
| ≤ 7.5 years follow-up (n=824) | 1.27 (1.18 – 1.37) | 1.21 (1.10 – 1.33) |
| > 7.5 years follow-up (n=725) | 1.21 (1.11 – 1.31) | 1.23 (1.12 – 1.35) |
| Cut point: 10.0 years follow-up | ||
| ≤ 10.0 years follow-up (n=1184) | 1.24 (1.16 – 1.32) | 1.20 (1.11 – 1.30) |
| > 10.0 years follow-up (n=365) | 1.26 (1.11 – 1.43) | 1.24 (1.07 – 1.43) |
| Cut point: 12.5 years follow-up | ||
| ≤ 12.5 years follow-up (n=1395) | 1.23 (1.16 – 1.31) | 1.19 (1.11 – 1.28) |
| > 12.5 years follow-up (n=154) | 1.34 (1.14 – 1.58) | 1.41 (1.15 – 1.72) |
a
Models adjusted for the following baseline characteristics: age, sex, steroid use, immunosuppressive use, ethnicity/location, SLE disease activity index (SLEDAI-2K), SLICC/ACR Damage Index (SDI), and SLE disease duration.
b
All incidence rate ratios are per 0.05 increase in baseline SLICC-FI score
Notes: SLICC = Systemic Lupus International Collaborating Clinics; FI = Frailty Index.