. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Kidney Int. 2020 Nov 5;99(6):1430–1438. doi: 10.1016/j.kint.2020.10.018

Table 2:

Incidence rate ratios for cancer among US kidney transplant recipients, by calendar decade of transplant

	Number of Cases			Unadjusted IRR (95%CI)^a		Adjusted IRR (95%CI)^{a, b}		P-Value for Trend
	1987–1996	1997–2006	2007–2016	1997–2006	2007–2016	1997–2006	2007–2016	Unadjusted	Adjusted^b
All Cancer	560	1848	970	1.13 (0.97, 1.32)	1.13 (0.95, 1.33)	0.98 (0.76, 1.26)	0.89 (0.67, 1.17)	0.158	0.398
Colorectum	41	97	38	0.81 (0.49, 1.36)	0.60 (0.32, 1.13)	0.79 (0.37, 1.70)	0.50 (0.20, 1.24)	0.112	0.137
Lung	75	216	93	0.99 (0.67, 1.46)	0.81 (0.51, 1.27)	0.74 (0.43, 1.26)	0.54 (0.29, 1.01)	0.354	0.054
Melanoma	29	85	53	1.01 (0.53, 1.92)	1.19 (0.59, 2.39)	0.68 (0.25, 1.83)	0.67 (0.22, 2.03)	0.624	0.475
Breast^c	37	105	53	0.98 (0.56, 1.73)	0.89 (0.47, 1.68)	0.68 (0.29, 1.62)	0.62 (0.23, 1.67)	0.709	0.343
Prostate^c	76	261	105	1.20 (0.82, 1.75)	0.91 (0.58, 1.41)	0.78 (0.46, 1.31)	0.48 (0.27, 0.86)	0.655	0.014
Kidney	39	205	148	1.81 (1.01, 3.22)	2.47 (1.36, 4.49)	1.37 (0.57, 3.24)	1.88 (0.74, 4.77)	0.003	0.182
NHL	75	188	122	0.86 (0.52, 1.42)	1.06 (0.62, 1.81)	0.85 (0.38, 1.90)	1.01 (0.41, 2.50)	0.834	0.984

Abbreviations: IRR incidence rate ratio, CI = confidence interval, NHL = non-Hodgkin lymphoma

Reference group is decade 1987–1996.

IRRs are adjusted for gender, age, race/ethnicity, body mass index, cause of ESKD, waiting time for transplant, kidney donor status (living vs. deceased), and induction and maintenance immunosuppression.

Breast cancer analyses are restricted to females, and prostate cancer analyses are restricted to males.

Bold text indicates results that are statistically significant (p < 0.05).