Table 1.
Indispensable genes in MYCN regulatory network.
| symbol | Full name | Indegree | Outdegree | Diseases associated |
|---|---|---|---|---|
| AURKA (58) | Aurora Kinase A | 1 | 6 | Colorectal Cancer/Colorectal Adenocarcinoma. |
| BANP (59) | BTG3 Associated Nuclear Protein | 3 | 1 | Keratoconus/Brittle Cornea Syndrome 2 |
| EGFR (60) | Epidermal Growth Factor Receptor | 4 | 2 | Inflammatory Skin/Bowel Disease, Neonatal, 2/Lung Cancer |
| FTH1 (61) | Ferritin Heavy Chain 1 | 2 | 1 | Hemochromatosis/Type 5 and Superficial Siderosis Of The Central Nervous System |
| MAX (62) | MYC Associated Factor X | 8 | 18 | Pheochromocytoma/Hereditary Paraganglioma-Pheochromocytoma Syndromes |
| MNT (63) | MAX Network Transcriptional Repressor | 1 | 2 | Tetanus Neonatorum/Mixed Type Thymoma |
| NME1 (64) | NME/NM23 Nucleoside Diphosphate Kinase 1 | 2 | 1 | Anal Canal Carcinoma/Larynx Cancer |
| NMI (65, 66) | N-Myc And STAT Interactor | 11 | 34 | – |
| SMAD3 (67) | SMAD Family Member 3 | 3 | 1 | Loeys-Dietz Syndrome 3/Familial Thoracic Aortic Aneurysm And Aortic Dissection |
| YEATS4 (68) | YEATS Domain Containing 4 | 1 | 5 | Cellular Myxoid Liposarcoma/Pleomorphic Liposarcoma |