Table 4.

Association between severity of PLE (5 categories) and externality.

Timepoint of PLE data collection (years)		14				16				22
		Unadjusted		Adjusted*		Unadjusted		Adjusted*		Unadjusted		Adjusted*
		OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
ALSPAC
Sample size n		3,704				3,221				2,199/2,066
Externality @ 8	None (ref cat)	1		1		1		1		1		1
	maybe	0.76	(0.57, 0.96)	1.23	(1.00, 1.45)	1.23	(1.00, 1.45)	2.02	(1.34, 2.70)	1.90	(1.58, 2.23)	1.45	(0.48, 2.42)
	Definite but not distressing or frequent	2.44	(2.22, 2.65)	2.58	(2.34, 2.83)	2.58	(2.34, 2.83)	3.39	(2.71, 4.07)	3.20	(2.85, 3.55)	2.75	(1.77, 3.73)
	Definite and distressing OR frequent	3.06	(2.83, 3.29)	3.24	(2.98, 3.50)	3.24	(2.98, 3.50)	4.05	(3.36, 4.74)	3.92	(3.53, 4.31)	3.47	(2.48, 4.47)
	Definite and distressing AND frequent	4.56	(4.24, 4.89)	4.81	(4.43, 5.18)	4.81	(4.43, 5.18)	5.62	(4.88, 6.36)	5.44	(4.84, 6.03)	5.00	(3.91, 6.09)
Sample size n		3,221
Externality @ 16	None (ref cat)									1		1
	Maybe									2.56	(2.30, 2.83)	2.45	(1.50, 3.40)
	Definite but not distressing or frequent									3.94	(3.62, 4.25)	3.83	(2.86, 4.79)
	Definite and distressing OR frequent									4.60	(4.24, 4.96)	4.49	(3.51, 5.47)
	Definite and distressing AND frequent									6.11	(5.52, 6.69)	6.01	(4.91, 7.09)
TTC
Sample size n	1,877
Externality @ 10	None (ref cat)	1		1
	Maybe	1.43	(1.19, 1.66)	1.50	(0.54, 2.45)
	Definite but not distressing or frequent	2.54	(2.28, 2.80)	2.60	(1.63, 3.56)
	Definite and distressing OR frequent	2.71	(2.44, 2.97)	2.76	(1.80, 3.73)
	Definite and distressing AND frequent	3.54	(3.23, 3.85)	3.61	(2.63, 4.59)

^*Adjusted for sex, IQ at age 8, home ownership status, parental marital status, parental educational level, family income.