Table 3.
Differences in biomarker concentrations between time points in patients with mTBI, calculated using post-hoc contrast analyses based on the linear mixed model results.
| Biomarkers | Acute−72 h | 72 h−2 weeks | 2 weeks−3 months | 3–12 months |
|---|---|---|---|---|
| Estimate‡ (95% CI) | Estimate‡ (95% CI) | Estimate‡ (95% CI) | Estimate‡ (95% CI) | |
| p-value | p-value | p-value | p-value | |
| GFAP | −0.45 (−0.53 to −0.37) | −0.25 (−0.30 to −0.20) | −0.09 (−0.14 to −0.04) | −0.02 (−0.07 to 0.03) |
| p < 0.0001 | p < 0.0001 | p = 0.001 | p = 0.405 | |
| NFL | 0.06 (−0.01 to 0.14) | 0.30 (0.26 to 0.35) | −0.23 (−0.27 to −0.19) | −0.17 (−0.21 to −0.12) |
| p = 0.086 | p < 0.0001 | p < 0.0001 | p < 0.0001 | |
| Tau | −0.20 (−0.25 to −0.14) | 0.06 (0.03 to 0.10) | −0.04 (−0.07 to −0.01) | −0.05 (−0.08 to −0.01) |
| p < 0.0001 | p = 0.001 | p = 0.024 | p = 0.011 |
‡
Estimate refers to mean timepoint differences as estimated by the mixed model; 95% CI is the 95% confidence interval of the estimated timepoint difference. All values are log transformed. Significant differences are bolded. Bonferroni-adjusted alpha level = 0.0125.
mTBI, mild traumatic brain injury; GFAP, Glial fibrillary acidic protein; NFL, Neurofilament light.