Table 1.
Administered tFUS conditions with constant TBD.
| tFUS conditionsa | PRF (Hz) | DC (%) | ISPTA (mW/cm2) |
|---|---|---|---|
| PRF 30 Hz | 30 | 0.6 | 1.05 |
| PRF 300 Hz | 300 | 6 | 10.55 |
| PRF 1500 Hz | 1,500 | 30 | 52.74 |
| PRF 3000 Hz | 3,000 | 60 | 105.48 |
| PRF 4500 Hz | 4,500 | 90 | 158.22 |
aExcept for the ultrasound pulse repetition frequency (PRF), the ultrasound duty cycle (DC), and the spatial-peak temporal-average intensity (ISPTA), all of the listed tFUS conditions keep the following parameters constant, i.e., ultrasound fundamental frequency (f0 = 500 kHz), ultrasound duration (UD = 67 ms), cycle per pulse number (CPP = 100), tone-burst duration (TBD = 200 µs), spatial-peak pulse-average intensity (ISPPA = 175.80 mW/cm2), and spatial-peak temporal-peak intensity (ISPTP = 351.61 mW/cm2). Note: the inter-sonication interval (ISoI) has a typical value of 2.5 s and has 10% jittering. This 10% jittering of the inter-stimulus interval is to minimize the timing effect and potential brain adaptation to the tFUS stimulation.