Table 2.
Characteristics of IgG4-related disease with tuberculosis infection in our cohort (2015-2020).
| Patient No. | Age, sex | Organ involvement | Serum IgG4 (g/L) | Tissue biopsy | Diagnosis of IgG4-RD | TB screen | Diagnosis of TB |
|---|---|---|---|---|---|---|---|
| 1 | 51, M | Lung | 3.43 | + | definite | TB-IGRA (T-N) 389.71 pg/ml; TST +; a history of tuberculous lymphadenitis | LTBI |
| 2 | 78, M | Retroperitoneal fibrosis | 17.00 | NA | possible | Night sweets, positive chest CT, TB-IGRA (T-N) 284.75 pg/ml, Xpert MTB/RIF + | TB |
| 3 | 54, M | Lymph node | 3.35 | + | definite | TB-IGRA (T-N) 60.2 pg/ml; TST + | LTBI |
| 4 | 61, M | Pancreas | 0.144 | + | probable | TB-IGRA (T-N) 19.49 pg/ml; TST - | LTBI |
| 5 | 51, M | Pancreas, biliary tract | 12.40 | + | definite | TB-IGRA (T-N) 23.88 pg/ml; TST + | LTBI |
| 6 | 65, M | Retroperitoneal and periorbital soft tissue, lymph node | 7.14 | – | possible | TB-IGRA (T-N) 145.58 pg/ml; TST + | LTBI |
| 7 | 52, M | Salivary gland | 0.177 | + | probable | TB-IGRA (T-N) 265.72 pg/ml; TST + | LTBI |
| 8 | 67, M | Liver | 2.15 | + | definite | TB-IGRA (T-N) 433.61 pg/ml; TST + | LTBI |
| 9 | 37, M | Periorbital soft tissue, lymph node | 10.70 | + | definite | TB-IGRA (T-N) 42.34 pg/ml | LTBI |
| 10 | 59, M | Periorbital soft tissue | 14.20 | + | definite | TB-IGRA (T-N) 90.27 pg/ml | TLBI |
| 11 | 40, M | Intracranial | 1.90 | + | definite | TB-IGRA (T-N) 413.7 pg/ml, a history of tubercular meningitis | LTBI |
| 12 | 26, F | Periorbital soft tissue | 2.13 | + | definite | TB-IGRA (T-N) 397.82 pg/ml; TST + | LTBI |
| 13 | 62, M | Retroperitoneal soft tissue | 27.80 | + | definite | TB-IGRA (T-N) 228.92 pg/ml; TST + | LTBI |
| 14 | 46, F | Lacrimal glands and salivary glands | 8.84 | + | definite | TST +; TB-IGRA (T-N) - | LTBI |
| 15 | 48, M | Lacrimal glands, pancreas | 15.10 | + | definite | Cough and night sweets, positive chest CT, TB-IGRA (T-N) 349.78 pg/ml; TST + | TB |
| 16 | 27, F | Cricoid cartilage, pancreas | 2.72 | + | definite | TB-IGRA (T-N) 54.56 pg/ml | LTBI |
| 17 | 68, M | Lacrimal glands, salivary glands, pancreas, lymph node, prostate | 23.10 | + | definite | TB-IGRA (T-N) 37.48 pg/ml | LTBI |
M, male; F, female; TB, tuberculosis; TST, tuberculosis skin test, induration ≥5 mm was considered positive; IGRA (T-N): interferon-gamma release assays for tuberculosis, (test minus nil control, normal range 0-14 pg/ml); tissue biopsy +: ratio of IgG4+/IgG+ or CD138+ plasma cell >40% and >10 IgG4+ plasma cell/HPF. The diagnosis of IgG4-RD was made according to the 2011 comprehensive criteria for IgG4-RD.