TABLE 2.

Antiviral properties of the restriction factors stabilized by SUMO3 in the presence of IFNα.

Protein stability	SUMO3/wt cells	(SUMO3/wt cells) + IFN	Viral resistance
IFN signaling
STAT1	+	+++
STAT2		+++
IRF9		+++
Restriction factors
MxA	+	+++	VSV, IAV, VACV
MxB		+++	HIV-1, HSV-1, HSV-2
GBP1		+++	VSV, IAV, DENV, KSHV
GBP5		+++	IAV, RSV, HIV-1
SAMHD1	+	+++	HIV-1, HSV-1, HBV, VACV
IFITM1		+++	ZIKV, DENV
IFITM2		+++	MLV, SARS-CoV-2
IFITM3		+++	MLV,VSV, IAV, IBV, DENV, SARS-CoV-2
IFIT1	+	+++	HBV, HPV, HCV
IFIT2		+++	VSV
IFIT3		+++	HBV, HPV, HCV
IFI44		+++	HIV-1, RSV
IFI44L		+++	HCV, RSV
TRIM21		+++	CVB3, HBV
Tetherin/BST2		+++	HIV-1, VSV, KSHV
PKR	+	+++	EMCV, VSV
ISG15		+++	IAV, IBV, Sindbis virus