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. 2021 Apr 21;12:666935. doi: 10.3389/fimmu.2021.666935

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Copyright © 2021 Rindler, Bauer, Jonak, Wielscher, Shaw, Rojahn, Thaler, Porkert, Simonitsch-Klupp, Weninger, Mayerhoefer, Farlik and Brunner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of a patient with advanced-stage mycosis fungoides (MF) with skin, blood, lymph node and internal organ involvement. (A) Histopathological evaluation of a skin biopsy showing an inflammatory infiltrate highly suspicious of MF, with T-cells showing partial loss of CD5, and total loss of CD7. (B) Flow-cytometric evaluation of peripheral blood mononuclear cells (PBMCs) showing a large T-cell population with CD7 loss within the CD3+CD4+ helper cell compartment. (C) Contrast-enhanced CT chest, abdomen and pelvis showing pathologically enlarged axillary and inguinal lymph nodes (arrows), and lesions to the lung (arrow heads) and the liver (circle) suspicious of CTCL manifestations. (D) Histopathological characterization of a diagnostic biopsy of an axillary lymph node, confirming CTCL involvement.