Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 21;12:666935. doi: 10.3389/fimmu.2021.666935

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Rindler, Bauer, Jonak, Wielscher, Shaw, Rojahn, Thaler, Porkert, Simonitsch-Klupp, Weninger, Mayerhoefer, Farlik and Brunner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Trajectory analysis highlighting tumor clone plasticity throughout body compartments. (A) Pseudotime ordering of malignant cells from clusters TC-1 and TC-3 along a bifurcated cell trajectory. Plot colored according to pseudotime. (B) Trajectory plot colored according to tissue of origin in red (LN: lymph node), green (PBMC, peripheral blood mononuclear cells), and blue (skin). (C) Trajectory plot colored according cell cycle phase in red (G1), green (G2/M) and blue (S). (D) Bifurcated expression heat map of genes for bifurcation between cell fates 1 and 2. Middle of heat map shows pre-branch cells, left side the expression of cells from “cell fate 1”, and right side the expression blood-oriented cells (“cell fate 2”). (E–G) Trajectory plots with overlaid expression of respective genes, highest expression in red, lowest expression in grey.