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. 2021 May 4;11:9520. doi: 10.1038/s41598-021-89086-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MAT attenuated the severity of optic nerve inflammation. (A) All rats described in Fig. 1 were euthanized and both sides of optic nerves were isolated and stained by H&E in transverse (upper row) and longitudinal (lower row) sections of optic nerves. Images were collected under the bright-field setting. Scale bars = 100 µm. (B) Degree of inflammatory cell infiltration in optic nerves. All results are expressed as mean ± SD (n = 40 per group: both transverse and longitudinal sections, both sides of optic nerves from 10 rats per group; 2 × 2 × 10 = 40 each group). Multiple comparisons were performed using one-way ANOVA, followed by Student–Newman–Keuls test. ***P < 0.001, comparison with the naive group. ^###P < 0.001, comparisons between vehicle- and MAT-treated groups.