TABLE 2.
Inferred Transcriptional Regulators (ITRs) for MYCN ChIP-seq samples belong to HDAC and SMARC families of epigenetic regulators.
| Inferred Transcriptional Regulator (ITR) | Dataset | p-value of overlap |
| HDAC family | KCNR | 2.04E–07 |
| 24h SY5Y-MYCN | 5.63E–06 | |
| 48h SY5Y-MYCN | 5.68E–06 | |
| KCN | 1.61E–05 | |
| HDAC1 | KCNR | 3.20E–03 |
| KCN | 6.02E–03 | |
| HDAC2 | KCN | 4.06E–05 |
| KCNR | 4.10E–05 | |
| 48h SY5Y-MYCN | 1.83E–02 | |
| 0h SY5Y-MYCN | 4.51E–02 | |
| HDAC4 | 48h | 1.20E–07 |
| KCN | 6.20E–05 | |
| KCNR | 1.30E–04 | |
| 0h SY5Y-MYCN | 1.18E–03 | |
| 24h SY5Y-MYCN | 2.70E–03 | |
| HDAC5 | 48h | 2.98E–02 |
| HDAC6 | 0h SY5Y-MYCN | 1.36E–02 |
| SMARCA1 | KCN | 4.04E–02 |
| SMARCA4 | 0h SY5Y-MYCN | 2.49E–02 |
| KCNR | 2.85E–02 | |
| SMARCB1 | KCN | 1.60E–02 |
| SMARCC1 | 0h SY5Y-MYCN | 4.96E–03 |
| KCN | 3.07E–02 | |
| 48h SY5Y-MYCN | 4.56E–02 | |
| SMARCD3 | 24h SY5Y-MYCN | 3.83E–04 |
| 0h SY5Y-MYCN | 9.48E–04 | |
| 48h SY5Y-MYCN | 1.61E–02 | |
| KCNR | 2.65E–02 | |
| SMARCE1 | 0h SY5Y-MYCN | 6.08E–03 |
| CREB1 (epigenetic related) | 0h SY5Y-MYCN 24h SY5Y-MYCN 48h SY5Y-MYCN KCN KCNR | 4.46E–08 1.28E–07 2.99E-16 1.56E–08 1.90E–08 |
MYCN ChIP-seq datasets are from MYCN-amplified KCN and KCNR cell lines and a MYCN overexpression time-course (un-induced [0 h], 24 h, and 48 h induction) in SY5Y-MYCN cells.