Table 5.

Association between lncRNAs polymorphisms and HCC.

lncRNA	Polymorphism type	Identifier	Samples	Association with HCC	Association with patient outcome	Functional experiments	Reference
GAS5	Indel polymorphism	rs145204276	1034 HCC patients and 1054 controls	Deletion allele is associated with increased risk of HCC.	Deletion allele is correlated with higher expression of GAS5 in HCC tissues.	Genotypes of this polymorphism are associated with methylation status of GAS5 promoter region.	(302)
KCNQ1OT1	Tetranucleotide repeat polymorphism (STR)	rs35622507	510 HCC patients and 1014 age and sex matched healthy controls	Heterozygote subjects with one allele 10 and those without allele 10 compared with subjects with homozygote 10–10 genotype have decreased risk of HCC.	–	Cell lines without allele 10 have higher expression of KCNQ1OT1.	(303)