Table 2.
Baseline and 1 year follow up data for patients within mild group (those with matched tests)
| CPET parameters | Baseline (n = 13) | Follow up (n = 13) | p value |
|---|---|---|---|
| VO2 peak (ml/kg/min) | 21.6 ± 2.9 | 19.1 ± 2.8 | 0.017 |
| VO2 peak at AT (ml/kg/min) | 14.2 ± 3.2 | 11.8 ± 1.6, n = 12 | 0.044 |
| VE peak (L/min) | 75.3 ± 20.9 | 66.1 ± 21.6 | 0.007 |
| VE peak % pred | 75.5 ± 13.2 | 65.9 ± 12.2 | 0.007 |
| VE/VCO2 at AT | 29.7 ± 3.1 | 31 ± 4.6, n = 12 | 0.353 |
| Minimum O2 saturation during CPET (%) | 91.5 ± 5.5 | 87.9 ± 6.6, n = 12 | 0.182 |
| Peak Work (W) | 106.9 ± 26.3 | 90.8 ± 25.9 | 0.022 |
| Peak Work (% predicted) | 44.3 ± 6.9 | 37.7 ± 8.5 | 0.002 |
| HR (bpm) | 142.3 ± 24.0 | 133 ± 22.3 | 0.040 |
| HR (% predicted) | 98.7 ± 16.9 | 91.8 ± 16.8 | 0.022 |
| BR max (L/min)(median, (IQR)) | 21.8 (12.4–34.2) | 33.8 (20.2–55.7) | 0.0002 |
| 6MWT | |||
| Distance achieved (m) | 346.9 ± 73.8 | 340.8 ± 72.4 | 0.563 |
| % theoretical distance (m) | 76.4 ± 18.3 | 76.0 ± 16.8 | 0.872 |
| Lung function | |||
| FVC % predicted | 98.8 ± 8.5 | 93.4 ± 10.3 | 0.010 |
| TLco % predicted | 62.3 ± 9.4 | 59.3 ± 11.8 | 0.161 |
VO2 peak peak oxygen consumption/kg; AT anaerobic threshold; VE minute ventilation; VCO2 carbon dioxide output; VCO2 ventilatory equivalent for carbon dioxide; VE/VCO2 BR max breathing reserve; W work; bpm beats per minute; % percentage; IQR interquartile range; n number; 6MWT 6 min walk test; FVC Forced Vital Capacity; TLco transfer factor; m metres; % percentage; CPET cardiopulmonary exercise testing. All values are shown as mean ± standard deviation, unless otherwise stated. Paired t-test was used for parametric data, whilst Wilcoxon matched pairs signed rank test was used for non-parametric data. A p < 0.05 was considered statistically significant