The economic burden of major depressive disorder (MDD) among US adults increased from $US236 billion in 2010 to $US326 billion in 2018 (year 2020 values); the share attributable to workplace costs increased from 48 to 61% because of more favorable employment conditions for adults with MDD.

Prevalence trends show that younger adults (aged 18–34 years) were increasingly affected by MDD compared with adults aged ≥ 35 years; adults aged 18–34 years accounted for 47.5% of the total prevalence in 2018 compared with 36.4% in 2010.

Substantial unmet treatment needs remain in the MDD population as the proportion of patients with MDD receiving treatment has not increased from 2010 to 2018.