Table 2.
Receptors and ligands of immune checkpoints (ICPs).
| ICP receptor | Expression pattern of receptors | ICP ligand | Expression pattern of ligands |
|---|---|---|---|
| PD-1 | Activated T cell B cell DC Macrophage |
PD-L1 | Antigen presenting cell Non-hematopoietic cell |
| PD-L2 | |||
| CTLA-4 | Activated T cell DC |
CD80 | Antigen presenting cell |
| CD86 | |||
| BTLA | Activated T cell Resting B cell Mature DC NK cells |
HVEM | T cell Macrophage DC |
| TIGIT | Activated T cell NK cell |
PVR | DC |
| PVRL2 | |||
| PVRL3 | |||
| VISTA / PD-1H | T cell NK cell DC Macrophage |
VSIG-3 | Neuron Glial cell |
| PSGL-1 | T cell B cell Macrophage DC |
||
| TIM-3 | T cell DC NK cell Macrophage |
Gal-9 | |
| Phosphatidyl serine | |||
| High mobility group protein B1 | |||
| Ceacam-1 | |||
| LAG-3 | Activated T cell B cell DC NK cell |
MHC class II | Antigen presentation cell |
| CD200R | T cell B cell Resting mast cell DC |
CD200 | Epithelial cell Endothelial cell Lymphoid cell Myeloid cell Neuron |