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. 2021 Apr 21;12:653940. doi: 10.3389/fphar.2021.653940

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Copyright © 2021 Geng, Ma, Jiang, Huang, Gao, Pu, Luo, Xu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune- Aging and Inflamm-Aging under Metabolic Stress in DW. ①Acute inflammation-mediated wound healing, tissue remodeling, and other orderly outcomes under the immune response in Non-DW. ②Inflamm-aging induced by metabolic pressure mediated tissue damage and hinders wound healing in DW. ③In the process cell senescence in DW, adaptive immunity significantly decreased, which is called immune-aging, while innate immunity is activated, thus inducing a unique pro-inflammatory response, which is called inflamm-aging.