TABLE 2.

EC₅₀ of two mixtures and compound 4 against Trypanosoma and Leishmania species (n = 3).

Compound/mixture	T. brucei s427	T. congolense IL3000 WT	T. equiperdum	T. evansi	L. mexicana
PAN-76 compounds 1 and 3 (µg/ml)	10.1 ± 1.0	44.1 ± 3.2	7.2 ± 0.6	4.3 ± 0.1	34.1 ± 11.2
HEAN-18 compounds 2 and 5 (µg/ml)	25.9 ± 2.6	194.8 ± 98.9	17.2 ± 2.6	ND	51.9 ± 3.8
HEAN 1 crude extract containing compound 4 (µg/ml)	5.7 ± 0.1	35.8 ± 4.3	7.3 ± 1.7	5.4 ± 0.1	10.1 ± 0.6
HEAN 19b compound 4 (µg/ml)	0.45 ± 0.02 (1.41 µM)	3.72 ± 0.54 (11.7 µM)	1.39 ± 0.27 (4.36 µM)	0.33 ± 0.05 (1.04 µM)	0.28 ± 0.05 (0.88 µM)
Diminazene (µM)	0.0878 ± 0.0355	0.228 ± 0.0446	0.0382 ± 0.0050	0.0438 ± 0.0005	ND
Suramin (µM)	0.0189 ± 0.0004	8.74 ± 1.634	0.021 ± 0.006	ND	ND
Pentamidine (µM)	ND	ND	ND	ND	0.786 ± 0.022

ND, not done.