TABLE 3.
Cross-resistance of two mixtures and compound 4 with existing drugs.
| Compound/mixture | T. brucei B48 | T. congolense 6C3 | ||
|---|---|---|---|---|
| RF | p value | RF | p value | |
| PAN-76 compounds 1 and 3 | 1.05 | 0.83 | 0.94 | 0.63 |
| HEAN -18 compounds 2 and 5 | 1.2 | 0.10 | 1.23 | 0.77 |
| HEAN 1 crude extract | 1.05 | 0.83 | 0.94 | 0.76 |
| HEAN 19b compound 4 | 1.38 | 0.27 | 1.12 | 0.69 |
| Diminazene | 5.70 | 0.19 | 6.96 | 0.014 |
| Suramin | 0.62 | 0.50 | 0.87 | 0.74 |
RF, resistance factor, being the ratio of the EC50 values of the resistant and control strains. p value was obtained using unpaired Student’s test between the EC50 values of the resistant line and control, obtained in parallel (n = 3).