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Toxicity of mixtures and compound 4 to HEK cells.
| Compound/mixture | EC 50 for HEK cells (n = 4) | Selectivity index (SI) | ||||
|---|---|---|---|---|---|---|
|
SI
T. brucei s427 |
SI
T. congolense IL3000 |
SI
T. equiperdum |
SI
T. evansi |
SI
L. mexicana |
||
| PAN-76 compound 1 and 3 (µg/ml) | 56.8 ± 2.7 | 5.65 | 1.29 | 7.92 | 13.3 | 1.67 |
| HEAN-1 crude (µg/ml) | 75.5 ± 6.6 | 13.6 | 2.11 | 10.4 | 13.9 | 7.45 |
| HEAN -19b compound 4 (µg/ml) | 9.39 ± 1.37 (29.5 µM) | 21.1 | 2.53 | 6.75 | 28.1 | 33.8 |
| PAO (µM) | 2.8 ± 0.08 | — | — | — | — | — |
