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. 2021 May 5;11(5):210009. doi: 10.1098/rsob.210009

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — HYPE crystallizes as an asymmetric dimer. (a) A cartoon representation of a HYPE monomer. Key structural features are highlighted. Asterisk represents missing electron density for 6 residues within the linker. The same structural features are present in the other HYPE monomer but has not been shown here for clarity. (b) HYPE residues involved in the formation of interfaces 1 and 2 are labelled. The HYPE monomers are depicted in green and red. Black solid lines (Dimer Interface 1 inset) denote hydrogen bonds between residues. Residues making up Dimer Interface 2 interact weakly, mostly through Vander-Waal's and electrostatic interactions.