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Food consumption and body weight of rats. Daily mean food consumption of (A) female and (B) male rats and mean body weight of (C) female and (D) male rats treated with different doses of AT-533 and single dose of AT-533 gel for 30 days (n=10). Data are presented as the mean ± SD. A separate one-way ANOVA analysis was performed for each time point. *P<0.05, **P<0.01, ***P<0.001 vs. vehicle group.
