Table I.
Hematological values of female rats treated with AT-533 or AT-533 gel for 30 days.
| Parameters | Control | Vehicle | 1 mg/kg | 2 mg/kg | 4 mg/kg | Blank gel | AT-533 gel |
|---|---|---|---|---|---|---|---|
| WBC (x109/l) | 4.69±2.49 | 5.59±0.85 | 8.63±3.83 | 9.96±5.64 | 17.32±4.40b | 5.53±1.73 | 4.74±2.42 |
| RBC (x1012/l) | 7.59±0.62 | 7.71±0.36 | 7.92±0.57 | 7.48±0.42 | 7.98±0.79 | 7.94±0.50 | 7.50±0.46 |
| HGB (g/l) | 151.33±13.49 | 148.50±5.58 | 149.67±11.09 | 136.67±6.98 | 145.20±12.34 | 156.50±9.33 | 143.67±7.74 |
| HCT (%) | 42.53±3.59 | 43.63±1.44 | 43.32±2.76 | 39.53±1.24a | 41.28±2.49 | 44.42±2.48 | 40.70±1.77 |
| MCV (fl) | 56.03±1.59 | 56.68±2.31 | 54.75±1.63 | 52.97±1.77b | 51.88±2.10b | 55.97±0.66 | 54.33±1.46 |
| MCH (pg) | 19.92±0.45 | 19.27±0.73 | 18.90±0.60 | 18.30±0.48a | 18.24±0.3a | 19.73±0.35 | 19.17±0.35 |
| MCHC (g/l) | 355.83±5.23 | 340.33±4.72 | 345.33±6.31 | 345.50±8.71 | 351.20±8.50a | 352.33±5.39 | 353.00±9.30 |
| PLT (x109/l) | 1,201.33±157.57 | 1,105.50±132.27 | 1,117.33±175.16 | 1,316.67±155.22 | 1,337.25±174.21 | 1,258.60±139.33 | 1,212.00±154.72 |
| RDW-SD (fl) | 27.38±1.42 | 28.28±0.70 | 28.30±0.83 | 27.45±0.97 | 28.12±0.62 | 27.88±1.78 | 25.97±1.02 |
| RDW-CV (%) | 15.10±1.33 | 15.62±1.33 | 16.52±1.05 | 16.42±1.55 | 17.62±1.68 | 16.08±1.62 | 14.77±1.40 |
| PDW (fl) | 9.65±0.52 | 9.47±0.60 | 9.42±0.52 | 8.70±0.37 | 9.72±0.73 | 9.50±0.21 | 9.32±0.47 |
| MPV (fl) | 8.67±0.41 | 8.57±0.46 | 8.43±0.37 | 8.02±0.23a | 8.40±0.21 | 8.57±0.29 | 8.32±0.23 |
| P-LCR (%) | 15.57±3.06 | 14.78±3.32 | 14.42±2.62 | 10.92±1.77 | 14.32±2.17 | 14.73±1.94 | 13.32±1.95 |
| PCT (%) | 1.04±0.11 | 0.95±0.12 | 0.94±0.14 | 1.05±0.12 | 1.05±0.18 | 1.07±0.09 | 0.95±0.19 |
| NE (x109/l) | 0.64±0.24 | 0.73±0.23 | 1.06±0.50 | 3.53±2.22a | 5.85±1.54c | 0.74±0.38 | 1.22±0.55 |
| LY (x109/l) | 4.01±2.54 | 4.66±0.84 | 7.13±3.65 | 5.84±3.53 | 10.37±3.48 | 4.68±1.37 | 4.31±3.10 |
| MO (x109/l) | 0.13±0.03 | 0.20±0.05 | 0.16±0.07 | 0.47±0.25 | 0.98±0.33 | 0.18±0.09 | 0.25±0.15 |
| EO (x109/l) | 0.08±0.06 | 0.09±0.02 | 0.10±0.07 | 0.12±0.08 | 0.09±0.07 | 0.13±0.09 | 0.08±0.03 |
| BA (x109/l) | 0.00±0.00 | 0.00±0.00 | 0.00±0.00 | 0.00±0.00 | 0.01±0.00 | 0.00±0.00 | 0.00±0.00 |
| NE (%) | 11.70±6.46 | 13.34±3.86 | 18.22±8.64 | 37.76±8.94b | 34.65±7.94 | 9.87±2.53 | 27.00±6.34e |
| LY (%) | 83.98±7.82 | 83.08±5.70 | 79.62±8.94 | 59.03±9.67b | 64.84±15.21a | 85.42±3.72 | 67.15±6.38e |
| MO (%) | 3.07±1.19 | 3.50±0.76 | 2.02±0.28 | 4.24±1.30 | 6.66±2.41a | 2.70±0.73 | 4.12±1.00 |
| EO (%) | 1.25±0.28 | 1.63±0.34 | 1.37±0.40 | 1.18±0.57 | 0.54±0.43c | 2.26±0.87 | 1.36±0.59 |
| BA (%) | 0.00±0.00 | 0.00±0.00 | 0.00±0.00 | 0.02±0.04 | 0.10±0.12a | 0.00±0.00 | 0.02±0.04 |
| RET (x109/l) | 233.42±43.40 | 243.38±30.01 | 257.95±41.78 | 197.48±50.31 | 227.48±75.54 | 282.12±37.05 | 270.95±78.70 |
| RET (%) | 3.09±0.59 | 3.16±0.42 | 3.29±0.70 | 3.02±1.12 | 2.86±0.95 | 3.55±0.40 | 3.62±1.01 |
| PT (s) | 9.43±0.34 | 9.02±0.30 | 8.68±0.25 | 8.60±0.33 | 9.36±2.00 | 9.62±1.40 | 9.13±0.52 |
| TT (s) | 45.47±4.15 | 40.77±6.06 | 49.33±5.12 | 37.75±4.21 | 44.74±6.95 | 47.28±4.19 | 42.05±4.19d |
Values are presented as the mean ± SD for 6 rats in each group (5 rats in the 4 mg/kg group).
aP<0.05,
bP<0.01,
cP<0.001 vs. vehicle.
dP<0.05,
eP<0.001 vs. blank gel. BA, basophil; EO, eosinophil; HCT, hematocrit; HGB, hemoglobin concentration; LY, lymphocyte; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; MO, monocyte; MPV, mean platelet volume; NE, neutrophil; P-LCR, PLT, platelet count; PT, prothrombin time; RBC, erythrocyte count; RDW, red cell distribution width; RET, reticulocyte count; TT, thrombin time; WBC, white blood cell count.