Table III.
Serum biochemical values of female rats treated with AT-533 or AT-533 gel for 30 days.
| Parameters | Control | Vehicle | 1 mg/kg | 2 mg/kg | 4 mg/kg | Blank gel | AT-533 gel |
|---|---|---|---|---|---|---|---|
| TP (g/l) | 62.85±4.06 | 55.87±4.46 | 64.40±11.77 | 51.58±9.53 | 50.90±7.73 | 63.58±3.78 | 59.25±7.33 |
| ALB (g/l) | 29.82±1.38 | 27.40±2.34 | 29.90±5.81 | 22.15±5.22 | 16.84±3.74c | 30.70±1.32 | 27.72±2.82a |
| ALT (U/l) | 57.67±21.34 | 42.17±6.31 | 39.17±11.69 | 57.50±20.04 | 79.60±25.83 | 53.83±10.25 | 62.25±7.63 |
| AST (U/l) | 126.80±18.67 | 83.17±5.34 | 102.33±43.57 | 182.50±94.05 | 316.50±229.56a | 103.50±11.43 | 165.00±45.21b |
| T-Bil (umol/l) | 0.12±0.09 | 0.12±0.05 | 0.24±0.13 | 0.19±0.11 | 0.14±0.07 | 0.10±0.10 | 0.15±0.16 |
| ALP (U/l) | 145.83±31.57 | 135.40±29.05 | 167.80±63.15 | 158.80±4.55 | 307.20±245.60 | 175.50±1.73 | 189.00±39.17 |
| BUN (mmol/l) | 7.03±1.72 | 5.85±0.70 | 5.89±0.98 | 6.19±1.16 | 8.20±3.79 | 6.56±0.86 | 6.43±0.70 |
| CRE (umol/l) | 35.05±10.73 | 23.77±3.69 | 30.88±8.51 | 33.35±6.96 | 28.24±10.03 | 33.27±6.67 | 27.55±4.18 |
| UA (umol/l) | 110.55±34.80 | 93.38±8.14 | 121.86±11.47 | 104.70±34.12 | 85.53±46.07 | 79.25±13.48 | 64.92±18.43 |
| GLU (mmol/l) | 19.88±4.06 | 15.93±3.38 | 17.12±1.93 | 13.65±2.55 | 12.36±4.07 | 16.88±2.16 | 15.69±3.89 |
| TG (mmol/l) | 0.97±0.55 | 1.30±0.84 | 0.99±0.53 | 1.02±0.48 | 0.49±0.07 | 0.75±0.34 | 1.01±0.44 |
| CHO (mmol/l) | 1.95±0.22 | 1.63±0.28 | 2.07±0.45 | 1.73±0.43 | 1.20±0.62 | 1.85±0.22 | 1.73±0.32 |
| HDL (mmol/l) | 0.77±0.11 | 0.66±0.15 | 0.81±0.18 | 0.74±0.20 | 0.52±0.29 | 0.74±0.09 | 0.72±0.15 |
| LDL (mmol/l) | 0.24±0.03 | 0.19±0.04 | 0.21±0.05 | 0.25±0.07 | 0.22±0.04 | 0.20±0.04 | 0.25±0.04d |
| CK (U/l) | 1,326.50±190.12 | 579.60±338.26 | 1,544.50±391.89 | 899.00±301.61 | 2,246.60±1528.21 | 1,594.83±679.49 | 1,627.20±784.94 |
| CK-MB (U/l) | 391.50±140.6 | 303.20±54.87 | 505.80±190.8 | 271.50±39.26 | 341.33±38.53 | 415.20±43.64 | 434.40±106.4 |
| K+ (mmol/l) | 5.50±0.66 | 5.22±0.90 | 5.81±1.35 | 6.18±1.80 | 5.34±1.04 | 5.05±0.83 | 5.87±1.42 |
| Na+ (mmol/l) | 141.32±6.21 | 125.38±6.51 | 132.37±18.12 | 129.52±18.95 | 130.88±10.78 | 141.48±7.59 | 141.92±5.21 |
| Cl- (mmol/l) | 109.62±2.78 | 100.88±4.85 | 105.02±15.9 | 101.28±18.31 | 104.50±7.69 | 109.65±3.25 | 111.07±5.67 |
Values are the mean ± SD for 6 rats in each group.
aP<0.05,
bP<0.01,
cP<0.001 vs. vehicle.
dP<0.05,
eP<0.01 vs. blank gel. ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, urea nitrogen; CHOL, cholesterol; Cl, chloride; CRE, creatinine; GLU, glucose; HDL, high-density lipoprotein cholesterol; K, potassium; LDL, low density lipoprotein-cholesterol; Na, sodium; T-Bil, total bilirubin; TG, triglycerides; TP, total serum protein; UA, uric acid.