Table IV.
Serum biochemical values of male rats treated with AT-533 or AT-533 gel for 30 days.
| Parameters | Control | Vehicle | 1 mg/kg | 2 mg/kg | 4 mg/kg | Blank gel | AT-533 gel |
|---|---|---|---|---|---|---|---|
| TP (g/l) | 61.30±6.22 | 59.12±8.13 | 57.15±9.59 | 50.88±9.44 | 48.78±4.55 | 60.78±3.86 | 62.98±3.86 |
| ALB (g/l) | 27.52±1.74 | 27.93±3.65 | 25.53±4.26 | 17.73±2.64c | 14.22±2.28c | 28.23±1.65 | 23.44±4.70d |
| ALT (U/l) | 53.00±5.35 | 52.80±13.65 | 42.50±9.65 | 38.80±6.26 | 133.83±143.50 | 55.00±16.49 | 54.50±14.84 |
| AST (U/l) | 124.50±16.8 | 138.80±30.7 | 100.17±21.4 | 94.33±32.6 | 272.50±156.2 | 116.00±18.6 | 120.50±46.3 |
| T-Bil (umol/l) | 0.11±0.05 | 0.44±0.14 | 0.23±0.18 | 0.06±0.07 | 0.24±0.20 | 0.13±0.06 | 0.07±0.06 |
| ALP (U/l) | 268.2±33.5 | 252.2±49.2 | 195.2±43.5 | 272.5±119.7 | 289.8±131.2 | 249.2±22.02 | 259.5±25.38 |
| BUN (mmol/l) | 6.60±0.96 | 5.86±1.30 | 5.30±0.73 | 5.43±2.08 | 15.46±9.61a | 6.78±1.28 | 6.42±0.45 |
| CRE (umol/l) | 27.34±5.90 | 25.90±5.68 | 23.92±7.13 | 20.10±8.60 | 23.03±10.80 | 29.47±3.91 | 40.88±8.23e |
| UA (umol/l) | 112.8±19.8 | 111.4±28.0 | 114.4±37.7 | 81.2±27.9 | 75.8±24.1 | 90.1±20.8 | 93.5±16.8 |
| GLU (mmol/l) | 17.24±1.84 | 16.69±3.03 | 14.28±2.23 | 13.06±3.09 | 9.84±2.36c | 20.56±2.89 | 17.60±5.92 |
| TG (mmol/l) | 1.84±0.35 | 2.16±0.67 | 1.52±0.42a | 1.03±0.08c | 0.35±0.18c | 1.71±0.22 | 0.96±0.56d |
| CHO (mmol/l) | 1.45±0.14 | 1.62±0.36 | 1.52±0.35 | 1.22±0.46 | 0.92±0.23b | 1.82±0.22 | 1.47±0.52 |
| HDL (mmol/l) | 0.60±0.04 | 0.68±0.16 | 0.61±0.14 | 0.55±0.20 | 0.37±0.12b | 0.74±0.11 | 0.58±0.21 |
| LDL (mmol/l) | 0.26±0.02 | 0.23±0.04 | 0.22±0.03 | 0.24±0.07 | 0.25±0.08 | 0.26±0.03 | 0.32±0.01f |
| CK (U/l) | 2,059.0±584.5 | 2,541.6±811.2 | 1,816.8±575.2 | 966.3±617.5b | 815.7±689.7b | 1,929.3±1224.6 | 1,681.0±787.1 |
| CK-MB (U/l) | 486.0±114.4 | 470.8±111.9 | 642.40±216.13 | 271.33±161.47 | 358.20±350.24 | 452.50±68.25 | 370.80±52.08 |
| K+ (mmol/l) | 6.61±0.99 | 5.68±1.46 | 5.59±1.69 | 6.10±2.82 | 4.86±2.10 | 5.72±0.53 | 5.18±0.94 |
| Na+ (mmol/l) | 140.64±3.74 | 132.28±11.46 | 127.92±16.86 | 119.87±23.25 | 120.10±22.52 | 143.08±4.79 | 149.24±3.35d |
| Cl- (mmol/l) | 109.88±4.43 | 105.68±8.89 | 101.83±13.63 | 98.44±16.09 | 93.42±23.34 | 111.67±4.55 | 117.60±3.10d |
Values are the mean ± SD for 6 rats in each group.
aP<0.05,
bP<0.01,
cP<0.001 vs. vehicle.
dP<0.05,
eP<0.01,
fP<0.001 vs. blank gel. ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, urea nitrogen; CHOL, cholesterol; Cl, chloride; CRE, creatinine; GLU, glucose; HDL, high-density lipoprotein cholesterol; K, potassium; LDL, low density lipoprotein-cholesterol; Na, sodium; T-Bil, total bilirubin; TG, triglycerides; TP, total serum protein; UA, uric acid.