Table 3.

Human receptors and enzymes involved in SARS-CoV-2, SARS-CoV, and MERS-CoV infection

Type of Coronavirus (Genebank accession number)	Disease	Genome sequence identity to SARS-CoV-2 (NC_045512.2) (%)	Receptor of interaction	Other proteases involved for fusion and activation of S-protein	Mortality rate (%)	PubMed IDs
SARS-CoV-2 (NC_045512.2)	COVID-19	100	ACE2; CD147	TMPRSS2; TMPRSS4; TMPRSS11a; TMPRSS11d; TMPRSS11e; Furin; trypsin; cathepsin, PIKFVE, TPC2	2.3	32170806, 32275855, 32307653, 32231345, 32221306, 32272173, 24098509, 32057769, 32234451
SARS-CoV (AY278488.2)	SARS	80.04	ACE2; CD209L	TMPRSS2; TMPRSS4; TMPRSS11a; TMPRSS11d; TMPRSS11e; Trypsin; Cathepsin, Elastase; Thermolysin	9.5	32015507, 30102747, 15496474, 32272173, 24227843, 32142651, 23468491, 32165541, 19924243, 19321428, 16339146, 20507992, 16116101, 32234451
MERS-CoV (KT225476.2)	MERS	54.86	DPP4 (CD26)	TMPRSS2; TMPRSS4; TMPRSS11a; TMPRSS11d; TMPRSS11e;Furin; Trypsin; Cathepsin, Elastase; Thermolysin	34.4	23486063, 32272173, 29976755, 24027332, 25288733, 30413791, 32234451, 32149036

ACE2 angiotensin-converting enzyme 2, DPP4 dipeptidyl peptidase 4, IHC immunohistochemistry, RNA-Seq RNA sequencing, TMPRSS transmembrane proteases serine subfamily, SARS severe acute respiratory syndrome, MERS Middle east respiratory syndrome, CoV coronavirus, COVID coronavirus disease